Myosin II-Dependent Suppression of Podosomes by an ARNO-ARF1 Signaling Axis
نویسندگان
چکیده
منابع مشابه
Podosome assembly is controlled by the GTPase ARF1 and its nucleotide exchange factor ARNO
Podosomes represent a class of integrin-mediated cell-matrix adhesions formed by migrating and matrix-degrading cells. We demonstrate that in macrophage-like THP1 cells and fibroblasts stimulated to produce podosomes, down-regulation of the G-protein ARF1 or the ARF1 guanine nucleotide exchange factor, ARNO, by small, interfering RNA or pharmacological inhibitors led to striking podosome elimin...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2017
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2016.11.2294